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Quality manufacturer supply 5-AMINOINDAZOLE 19335-11-6 in stock with high standard
- Molecular Formula: C7H7N3
- Molecular Weight: 133.153
- Appearance/Colour: white to light yellow crystal powder
- Vapor Pressure: 5.92E-10mmHg at 25°C
- Melting Point: 175-178 °C
- Refractive Index: 1.806
- Boiling Point: 376.609 °C at 760 mmHg
- PKA: 14.52±0.40(Predicted)
- Flash Point: 209.521 °C
- PSA： 54.70000
- Density: 1.367 g/cm3
- LogP: 1.72630
5-AMINOINDAZOLE(Cas 19335-11-6) Usage
|
Application |
1H-Indazol-5-amine is a useful research chemical, an indazole derivatives with anti- inflammatory properties. |
InChI:InChI=1/C6H6N4/c7-4-1-5-6(8-2-4)10-3-9-5/h1-3H,7H2,(H,8,9,10)
19335-11-6 Relevant articles
Design, synthesis and biological evaluation of indazole-pyrimidine based derivatives as anticancer agents with anti-angiogenic and antiproliferative activities
Elsayed, Nevine M. Y.,Abou El Ella, Dalal A.,Serya, Rabah A. T.,Tolba, Mai F.,Shalaby, Raed,Abouzid, Khaled A. M.
, p. 881 - 899 (2016)
Three series of novel indazole-pyrimidin...
Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity
Elsayed, Nevine M.Y.,Serya, Rabah A.T.,Tolba, Mai F.,Ahmed, Marawan,Barakat, Khaled,Abou El Ella, Dalal A.,Abouzid, Khaled A.M.
, p. 340 - 359 (2019)
VEGFR-2 has a pivotal role in promoting ...
Design, synthesis, and biological evaluation of new B-RafV600E kinase inhibitors
Wang, Peng-Fei,Zhang, Yong-Jiao,Wang, Dong,Hu, Hui-Min,Wang, Zhong-Chang,Xu, Chen,Qiu, Han-Yue,Zhu, Hai-Liang
, p. 2372 - 2380 (2018)
The association of deregulated signal pa...
PYRROLIDINYL-BASED COMPOUNDS
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Paragraph 0137, (2021/04/10)
Disclosed herein are pyrrolidinyl-based ...
COMPOUND SERVING AS IRAK INHIBITOR
-
Paragraph 0199-0200, (2021/10/07)
The present disclosure relates a compoun...
2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof
-
Paragraph 0197; 0298-0300, (2020/03/03)
The invention relates to 2-pyridine subs...
Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists
Kang, Jin Mi,Kwon, Sun Ok,Ann, Jihyae,Blumberg, Peter M.,Ha, Heejin,Yoo, Young Dong,Frank-Foltyn, Robert,Lesch, Bernhard,Bahrenberg, Gregor,Stockhausen, Hannelore,Christoph, Thomas,Lee, Jeewoo
, (2020/10/06)
A series of 1-indazol-3-(1-phenylpyrazol...
19335-11-6 Process route
-
-
5401-94-5
5-nitroindazole
-
-
19335-11-6
1H-indazol-5-ylamine
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
at 25 ℃;
Autoclave;
Inert atmosphere;
|
100%
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
under 760.051 Torr;
|
97%
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
under 1551.49 Torr;
|
97%
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
under 1551.49 Torr;
|
97%
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 40 ℃;
under 1551.49 Torr;
|
97%
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 40 ℃;
for 3h;
under 1551.49 Torr;
|
97.2%
|
|
With
hydrazine;
palladium on activated charcoal;
In
methanol;
Heating;
|
90%
|
|
With
potassium tert-butylate; isopropyl alcohol; bis(pinacol)diborane;
at 110 ℃;
for 2h;
|
88%
|
|
With
palladium on activated charcoal; hydrogen;
In
methanol;
for 12h;
|
88%
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 2h;
|
65%
|
|
With
ammonium hydroxide; iron(II) sulfate;
|
|
|
With
hydrogenchloride; zinc;
|
|
|
With
nickel;
Hydrogenation;
|
|
|
With
hydrogenchloride; palladium dihydroxide;
In
methanol;
|
|
|
With
iron; acetic acid;
|
|
|
With
iron; ammonium chloride;
In
ethanol; water;
for 2h;
Reflux;
|
|
|
With
palladium 10% on activated carbon; hydrazine hydrate;
In
ethanol;
for 0.166667h;
Reflux;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 1.5h;
|
|
|
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
|
190.6 mg
|
|
With
palladium on activated charcoal; hydrogen;
In
methanol;
at 20 ℃;
|
|
|
With
palladium on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 16h;
|
-
-
5401-94-5
5-nitroindazole
-
5-amuio-1H-indazole
-
5-amuio-1H-indazole
-
-
19335-11-6
1H-indazol-5-ylamine
| Conditions | Yield |
|---|---|
|
carbon palladium;
In
methanol;
|
100%
|
19335-11-6 Upstream products
-
5401-94-5
5-nitroindazole
-
99-52-5
2-methyl-4-nitro-benzenamine
19335-11-6 Downstream products
-
15579-15-4
5-hydroxy-1H-indazole
-
6635-98-9
4-(1(2)H -indazol-5-ylazo)-1(2)H -indazol-5-ol
-
118142-45-3
(1H-Indazol-5-yl)-(1-phenethyl-piperidin-4-ylidene)-amine
-
128924-78-7
C15 H14 N4 O3 S
